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An overview of ozanimod as a therapeutic option for adults with moderate-to-severe active ulcerative colitis
Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract involving a dysregulated immune response. Sphingosine-1-phosphate (S1P) is involved in immune cell regulation. S1P-receptor modulators, such as ozanimod, inhibit lymphocyte migration and have therapeutic potential in UC.
Areas covered: Ozanimod is the first S1P-receptor modulator approved for the treatment of UC. It acts as a functional antagonist, causing internalization of S1P receptors on T-cells. Lymphocyte Expert Option模擬賬戶教程 egress from lymph nodes is inhibited, and migration to sites of active inflammation is curtailed. There are several S1P-receptor subtypes, present in various organs, which inform understanding of ozanimod's side-effect profile including bradycardia and macular edema. In this review, the authors discuss the mechanism of action, pharmacokinetics, clinical efficacy, and safety profile of ozanimod in the treatment of patients with moderate-to-severe UC.
Expert opinion: The S1P-receptor modulator ozanimod is an oral small molecule with a rapid onset of action and a novel therapeutic mechanism in the treatment of UC. It is an effective treatment both in bio-naïve and bio-exposed patients. Although the safety profile of ozanimod looks favorable, more long-term data are needed. Further Expert Option模擬賬戶教程 studies are required to compare ozanimod to currently available therapies to best define its positioning in UC treatment algorithms.
Keywords: Inflammatory bowel disease; ozanimod; small molecules; sphingosine-1-phosphate receptor modulators; ulcerative colitis.
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Best Options Trading Software
Trading options is the process of buying and selling stocks at a pre-negotiated price by a certain date. Options are a type of contract that gives the trader the right to buy or sell a particular stock in the future, but does not require them to eat the losses should they Expert Option模擬賬戶教程 choose not to buy. And when you're trading, your profits are only as good as the platform you use. Here are Benzinga's favorites.
Quick Look - Best Options Trading Software:
The Best Options Trading Platforms
Based on the criteria above, we chose the best options trading platforms.
Featured Options Platform: Tradier
Tradier is a high-tech broker for active traders. Tradier differentiates itself by using application programming interface (API) technology to partner with popular trading software to offer a wide range of platform choices.
Tradier invented the idea of Expert Option模擬賬戶教程 an API-integrated brokerage firm with customizable interface options. Most brokers lock you into a pre-set interface, allowing you limited ways to customize your trading station, but not Tradier. You can integrate your platform of choice into your Tradier workstation while you take advantage of Tradier’s low fees and commissions.
Tradier is compatible with a wide range of platforms:
- Esignal
- Orion Multi Trader
- Stockstotrade
- Q.ai
- Screener.co
- 1Option
- eSignal
- And more!
Its tradable assets include stocks, options and ETFs and its TradeHawk mobile platform is available for an additional fee with fast-streaming data options.
It requires a Expert Option模擬賬戶教程 $0 minimum investment and two fee schedules. The standard equity and options trading comes with $0 fees per order and $0.35 per contract. If you’re a particularly active trader, you might prefer Tradier’s all-inclusive subscription model.
- It’s $30 Expert Option模擬賬戶教程 a month for commission-free equity and options trading. Expert Option模擬賬戶教程
- You’ll pay $10 for broker-assisted trades, which is significantly less expensive than competing brokers.
- Tradier’s current margin rate is 5.25% for all traders, no matter how much margin you use.
Options contracts are like "betting" on the movement of a stock — if you think a stock will increase in value but you're not ready to commit to a purchase right now, you can "lock in" a price (called a "strike price") to buy at a later date.
Many beginning investors choose to lace their money into the options trading market rather than stocks, bonds or forex because it requires less of an initial investment and gives the trader more time to see how the Expert Option模擬賬戶教程 stock will move before spending money. Just like how stockbrokers have largely moved their practices online, you can now buy and sell options from the comfort of your own home.