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An overview of ozanimod as a therapeutic option for adults with moderate-to-severe active ulcerative colitis
Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract involving a dysregulated immune response. Sphingosine-1-phosphate (S1P) is involved in immune cell regulation. S1P-receptor modulators, such as ozanimod, inhibit lymphocyte migration and have therapeutic potential in UC.
Areas covered: Ozanimod is the first S1P-receptor modulator approved for the treatment of UC. It acts as a functional antagonist, causing internalization of S1P receptors on T-cells. Lymphocyte egress from lymph nodes is inhibited, Expert Option 行動應用程式 and migration to sites of active inflammation is Expert Option 行動應用程式 Expert Option 行動應用程式 curtailed. There are several S1P-receptor subtypes, present in various organs, which inform understanding of ozanimod'Expert Option 行動應用程式 s side-effect profile including bradycardia and macular edema. In this review, the authors discuss the mechanism of action, pharmacokinetics, clinical efficacy, and safety Expert Option 行動應用程式 Expert Option 行動應用程式 profile of ozanimod in the treatment of patients with moderate-to-severe UC.
Expert opinion: The S1P-receptor modulator ozanimod is an oral small molecule with a rapid onset of action and a novel therapeutic mechanism in the treatment of UC. It is an effective treatment both Expert Option 行動應用程式 in bio-naïve and bio-exposed patients. Although the safety profile of ozanimod looks favorable, more long-term data are needed. Further studies are required to compare ozanimod to currently available therapies to best define its positioning in UC treatment algorithms.
Keywords: Inflammatory bowel disease; ozanimod; small molecules; sphingosine-1-phosphate receptor modulators; ulcerative colitis.
Choi D, Stewart AP, Bhat S. Choi D, Expert Option 行動應用程式 et al. Ann Pharmacother. 2022 May;56(5):Expert Option 行動應用程式 592-599. doi: 10.1177/10600280211041907. Epub 2021 Aug 22. Ann Pharmacother. 2022. PMID: 34423657 Review.
Aoun R, Hanauer S. Aoun R, et al. Expert Rev Gastroenterol Hepatol. 2022 May;16(5):411-423. doi: 10.1080/17474124.2022.2065258. Expert Rev Gastroenterol Hepatol. 2022. PMID: 35400292 Review.
Antonelli EK, Del Sordo R, Morelli O, Villanacci V, Bassotti G. Antonelli EK, et al. Drugs Today (Barc). 2022 Jul;58(7):351-367. doi: 10.1358/dot.2022.58.7.3408818. Drugs Today (Expert Option 行動應用程式 Barc). 2022. PMID: 35851870 Review.
Argollo M, Furfaro F, Gilardi D, Roda G, Allocca M, Peyrin-Biroulet L, Danese S. Argollo M, et al. Expert Opin Biol Ther. 2020 Apr;20(4):413-420. doi: 10.1080/14712598.2020.1732919. Epub 2020 Feb 25. Expert Opin Biol Ther. 2020. PMID: 32093531 Review.
Sandborn WJ, Feagan BG, Wolf DC, D'Haens G, Vermeire S, Hanauer SB, Ghosh S, Smith H, Cravets M, Frohna Expert Option 行動應用程式 PA, Aranda R, Gujrathi S, Olson A; Expert Option 行動應用程式 TOUCHSTONE Study Group. Sandborn WJ, et al. N Expert Option 行動應用程式 Engl J Med. 2016 May 5;374(18):1754-62. doi: 10.1056/NEJMoa1513248. N Engl J Med. 2016. PMID: 27144850 Clinical Trial.
Select advanced parameters
If you choose "Expert" mode:
Then you will have chances to choose the extra parametrs you want. Here we just press enter to accept the default settings:
Choose the option "" (Use the partition table from image)
If Expert Option 行動應用程式 the target disk size is larger than the source disk, you can try to use option "-k1" which will create the partition table proportionally in the target disk and turn on option "-r" to resize the file file system in the partition automatically. This is useful Expert Option 行動應用程式 to make use all of the target disk size.
For more details about the advanced parameters of Clonezilla live, please check this FAQ/Q&A.